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NFL Week 6 Predictions 2026: The QB and Injury Forks Behind Every Line on Kalshi

NFL Week 6 predictions built for an early week with no injury reports yet: every game at its Monday Kalshi price and DraftKings line, the QB and injury forks that decide each one (Lamar Jackson, Michael Penix Jr., Baker Mayfield, CeeDee Lamb, Deebo Samuel), and where the carries and targets went the last time each player sat.

Quick Answer

As of October 12, 2026, NFL Week 6 on Kalshi (8 AM ET Monday, Oct. 12): the Rams (86¢), Chiefs (79¢) and 49ers (78¢) are the biggest favorites; Saints–Giants and Cowboys–Packers are coin flips. With no injury reports out yet, five forks decide the slate: Lamar Jackson (Ravens priced with Huntley), Michael Penix Jr.'s ribs (Bears–Falcons shown both ways), Baker Mayfield's thumb (Bucs priced with Jalon Daniels), CeeDee Lamb's quad and Deebo Samuel's hamstring.

NFL Week 6 Kalshi board on Monday, Oct. 12: Rams 86 cents against Arizona as the week's biggest favorite, Ravens 70 cents at Cleveland with our board pricing Tyler Huntley, and the five quarterback and injury forks that decide the slate
NFL Week 6 Kalshi board on Monday, Oct. 12: Rams 86 cents against Arizona as the week's biggest favorite, Ravens 70 cents at Cleveland with our board pricing Tyler Huntley, and the five quarterback and injury forks that decide the slate
The 7 Oracles
The PredictionMarketsPicks Oracles
October 12, 2026

It's Monday. Week 5 isn't even over, and no team has filed a Week 6 injury report. So this isn't a list of picks. It's a list of forks: for every game, what we're watching, why it matters, and what changes if it breaks one way or the other. Every price is Kalshi at 8 AM ET Monday, Oct. 12. Every line is DraftKings via ESPN from the same morning, with its opener beside it. Every usage number comes from the ESPN box scores for Weeks 1–5.

How to read this page

Each game gets three lines:

A Kalshi price is the market's probability: 70¢ means a 70% chance. A fork is not a call. It's the question the market hasn't answered yet.

The Week 6 board

Kickoff (ET)GameKalshi (Mon 8 AM)DraftKings spread (open → now)Total (open → now)QB status on our board
Thu 8:15 PMSeahawks at BroncosSeahawks 60¢DEN +2.5 → SEA −343.5 → 41.5Set
Sun 9:30 AM, LondonTexans vs. JaguarsJaguars 58¢HOU −1.5 → JAX −341.5 → 43.5Set
Sun 1 PMBears at FalconsBears 63¢CHI −3 → CHI −347.5 → 47.5Fork: Penix / Tagovailoa
Sun 1 PMRavens at BrownsRavens 70¢BAL −6.5 → BAL −4.544.5 → 40.5Priced with Huntley
Sun 1 PMTitans at ColtsColts 75¢IND −3.5 → IND −748.5 → 44.5Set
Sun 1 PMJets at PatriotsPatriots 76¢NE −9.5 → NE −742.5 → 44.5Set
Sun 1 PMSaints at GiantsSaints 50¢ / Giants 49¢NYG −2.5 → NO −1.545.5 → 44.5Priced with Winston
Sun 1 PMPanthers at EaglesEagles 51¢PHI −6.5 → PHI −1.543.5 → 42.5Set
Sun 1 PMSteelers at BuccaneersSteelers 58¢TB −1.5 → PIT −345.5 → 40.5Priced with Daniels
Sun 4:05 PMCardinals at RamsRams 86¢LAR −13.5 → LAR −12.546.5 → 52.5Set
Sun 4:25 PMChargers at ChiefsChiefs 79¢KC −2.5 → KC −8.546.5 → 42.5Set
Sun 4:25 PMBills at RaidersBills 71¢BUF −6.5 → BUF −647.5 → 52.5Set
Sun 8:20 PMCowboys at PackersPackers 51¢GB −3 → GB −1.551.5 → 52.5Set
Mon 8:15 PMCommanders at 49ers49ers 78¢SF −5.5 → SF −7.550.5 → 50.5Set

Kalshi prices are mid-prices, rounded. ESPN's archive carries no timestamp for an opener, so we don't say what moved a line, only that it moved. The Bengals, Dolphins, Lions and Vikings are on bye. The full week, with every spread ladder, is on the Week 6 schedule.

The five forks that decide the week

1. Lamar Jackson's ankle: Ravens at Browns

Watching: whether Jackson practices this week. He missed Sunday night in Atlanta with an ankle injury, and Tyler Huntley started.

Why: the usual read is that no Lamar means more Derrick Henry. Sunday didn't show it. Henry carried 24 times for a 69% share of Baltimore's rushes. In Weeks 1–4 with Jackson, he averaged 22.25 carries and 70%. What changed was the passing: Huntley threw 32 times (24 of 32, 201 yards, 2 TDs), more than Jackson did in any game this season. Zay Flowers still drew 9 of 31 targets. Justice Hill was the one who grew, with 4 carries for 73 yards and 4 targets, his most of the season.

If Jackson is out again: Henry's carries probably look like any other week, and the volume to watch is Huntley's attempts and Hill's touches. Kalshi already has the Ravens at 70¢ with Huntley on our board, and the DraftKings total has dropped from 44.5 to 40.5. If he's in: our board is priced for the wrong quarterback, and this is the first game page that changes. Live board: Ravens at Browns.

On the Cleveland side, Quinshon Judkins has handled 52–63% of the carries every week (14 on Sunday), and running back Raheim Sanders (hip) and right tackle Tytus Howard (knee) left Sunday's loss in the fourth quarter, per the AP.

2. Michael Penix Jr.'s ribs: Bears at Falcons

Watching: Penix's practice status. He left Sunday night's overtime loss with a rib injury and Tua Tagovailoa finished. Penix predicted he will return next week, per the AP.

Why: Penix has been efficient in his three starts: 18 of 25, 15 of 20 and 19 of 32, never under 223 yards. Drake London has drawn 30–43% of the targets in all three. On the other side, Chicago has started three quarterbacks this season. Tyson Bagent started Weeks 4 and 5, with Caleb Williams out for a third straight game on Sunday (hamstring). In Bagent's Week 4 start, Kyle Monangai carried 30 times for 146 yards. Monangai missed Sunday (toe, thumb), and Chicago's running game shrank to 24 attempts. Roschon Johnson filled in with 5 carries and 7 targets.

If Penix plays: our board's Penix version applies, and Kalshi has the Bears at 63¢ as of Monday. If it's Tagovailoa: the page already shows that version. This is a fork on our board, so it carries both lines until Atlanta names a starter. The Chicago fork is Monangai: if he's back, Chicago's run game with Bagent looked like Week 4. If not, it's D'Andre Swift and a committee. Live board: Bears at Falcons.

3. Baker Mayfield's thumb: Steelers at Buccaneers

Watching: whether Mayfield gets back from the thumb injury that has kept Jalon Daniels under center for two weeks.

Why: our board prices this game with Daniels. Separately, the DraftKings line has gone from Tampa Bay −1.5 to Pittsburgh −3, and the total from 45.5 to 40.5. With Daniels starting, Tampa Bay leaned on Bucky Irving: 16 and 21 carries the last two weeks, and 165 yards against Dallas on Thursday.

If Mayfield is back: the total is the number that should move most. If not: Irving's volume is the most reliable thing in this game. For Pittsburgh, Roman Wilson left Sunday with a hand injury after one target, per the AP (doubtful on ESPN's in-game list), and Germie Bernard drew 9 of 30 targets on Sunday. Live board: Steelers at Buccaneers.

4. CeeDee Lamb's quad: Cowboys at Packers, Sunday night

Watching: Lamb's status after the quad injury from Thursday night's loss to Tampa Bay. Dallas gets ten days between games.

Why: in Week 4, Lamb drew 21 of Dallas's 43 targets. Hurt in Week 5, he drew five and caught two for nine yards, and George Pickens took 13 targets for 130 yards. Prescott has thrown 40-plus passes three weeks running, so whoever is on the field gets fed.

If Lamb is limited or out: Pickens is the target, and his last two "with Lamb" weeks were 11 and 3 targets. That's the range you're paying for. If Lamb is fine: Week 4 is the template. This is also one of three games where our screen currently flags a position: Green Bay to win, MODERATE, at 50.5¢, where the books' line implies 54.4%. Kalshi has it at 51¢. Green Bay lost defensive tackle Javon Hargrave late in Sunday's game to what Matt LaFleur believes is an Achilles injury, per the AP. Live board: Cowboys at Packers.

5. Deebo Samuel's hamstring: Commanders at 49ers, Monday night

Watching: Samuel, who hurt his hamstring on the play he fumbled Sunday in Seattle and didn't return, per the AP.

Why: in that game, which Samuel left late in the third quarter, Mike Evans drew 10 of 27 targets (37%) for 113 yards. George Kittle drew six, the same as Week 4.

If Samuel sits: Evans' target share is the number. If he plays: expect it back near the 21–28% Evans ran in Weeks 1 and 4. On the Washington side, Jayden Daniels ran 9 times for 103 yards on Sunday after the elbow that had our board forked last week, and Terry McLaurin returned from his hamstring. The screen also flags Washington here, MODERATE, at 22.5¢. Live board: Commanders at 49ers.

The rest of the slate

Seahawks at Broncos (Thursday). Watching: Denver's corners. Pat Surtain II (ankle) and Riley Moss (ribs) both missed Sunday, and this is a short week. Why: Jaxon Smith-Njigba has drawn at least 29% of Seattle's targets in every game. If both corners sit again, that's the matchup. And the one that doesn't matter: Zach Charbonnet's torn ACL. He hasn't had a carry in five games, and Emanuel Wilson took 77% of the carries on Sunday. Kalshi: Seahawks 60¢. Game page.

Texans vs. Jaguars (London). Watching: David Montgomery's groin. DeMeco Ryans said he may miss some time, per the AP. Why: Woody Marks took 15 of Houston's 27 carries (56%) on Sunday; Montgomery had 5 before he left in the second quarter. In Weeks 1–4 Marks never had more than 9. If Montgomery is out, Marks is the lead back. Jacksonville's fork is up front: left tackle Anton Harrison was carted off with a knee injury, per the AP. The line has moved 4.5 points toward Jacksonville. Game page.

Titans at Colts. Watching: the line more than the injury report. It's gone from Indianapolis −3.5 to −7 and the total from 48.5 to 44.5. Tennessee corner Cor'Dale Flott didn't return Sunday (chest). Colts 75¢. Game page.

Jets at Patriots. Watching: TreVeyon Henderson (ankle) and left tackle Will Campbell (knee). Neither returned Sunday, per the AP. Why: Henderson had 4 carries before he left; Rhamondre Stevenson (13) and Corey Kiner (6) carried the rest of the load. For the Jets, Kenyon Sadiq is in the concussion protocol, per the AP, and Garrett Wilson drew 11 of 29 targets without much help. Patriots 76¢. Game page.

Saints at Giants. Watching: the Giants' line, after right tackle Jermaine Eluemunor was carried off with a calf injury. Why: Jameis Winston threw 54 times in Sunday's tie, and Malik Nabers drew 20 targets. That's a volume number, not a sustainable one. The line flipped from Giants −2.5 to Saints −1.5, and Kalshi has it as a coin flip. Game page.

Panthers at Eagles. Watching: Philadelphia's defense after London. Jonathan Greenard (ankle) missed Sunday, and Jalyx Hunt and Michael Carter II were hurt. Carolina is coming off its bye; the Eagles are coming back from London. Why it matters: the line has moved five points, from Philadelphia −6.5 to −1.5. Our screen still holds an Eagles position entered Oct. 6 at 55¢. Kalshi now has Philadelphia at 51¢, so the market has moved against it. Game page.

Cardinals at Rams and Bills at Raiders. Watching: tonight. Both the Rams and Bills play Monday night and get a short turnaround. Both totals have jumped five or more points since they opened (Cardinals–Rams 46.5 to 52.5, Bills–Raiders 47.5 to 52.5). Anything that comes out of tonight's game moves these two first. Cardinals at Rams · Bills at Raiders.

Chargers at Chiefs. Watching: the Chargers' receiver room. Quentin Johnston (chest) and Brenen Thompson (quadriceps) missed Sunday, and Tre' Harris left with a hamstring injury. Justin Herbert threw for 121 yards and no Charger had more than four targets. Why: the line has gone from Kansas City −2.5 to −8.5, the biggest spread move of the week, and the Chargers are 0-5. Chiefs 79¢. Game page.

Look-ahead: the Vikings' targets (Week 7)

Minnesota is on bye this week, so this one waits for Colts at Vikings on Oct. 25. But the bye week is when this gets decided. T.J. Hockenson was helped off Sunday after hitting his head, per the AP (ESPN lists a concussion), and Jordan Addison didn't appear in Sunday's box score.

Here's what Minnesota looked like with Addison out and Hockenson gone early (one target). Kyler Murray's 30 attempts produced 29 targets: Justin Jefferson 7 (24%), tight end Gavin Bartholomew 6, Myles Price 4, Tai Felton 3, Aaron Jones 3. Bartholomew had one target all season before Sunday. And when Jefferson missed Week 4, Hockenson soaked up 13 targets and caught all 13. If both Hockenson and Addison are out for Week 7, Jefferson's share and Bartholomew's role are the two numbers to price. We'll write it up when the Week 7 prices list.

What our screen flags right now

Three games clear our screen on Monday morning, all MODERATE: Green Bay against Dallas, Washington at San Francisco, and Philadelphia against Carolina. Each is a gap between Kalshi's price and the probability the books' line implies, not a forecast of the score. The screen reprices every time the market moves, and an injury report can erase a gap in an hour. The live list is on the NFL edges board.

NFL Week 6 edge board, live: where Kalshi and the books' line disagree right now, not on Monday morning. · Open the full tool →

When this page updates

Wednesday, after the first injury reports. Friday, after final statuses. Every fork above will have resolved one way or the other by then, and the game pages flip with it. Kalshi lists Week 6 player props later in the week. When it does, the strikes worth watching are the ones above: Henry and Hill, Marks, Irving, Pickens, Evans, Smith-Njigba. They'll be on the prop board with the books beside them.

This week's NFL prop board, live: our projection against every Kalshi strike. · Open the full tool →

NFL Week 6 Predictions 2026: The QB and Injury Forks Behind Every Line on Kalshi — frequently asked

Who are the biggest favorites in NFL Week 6?

On Kalshi at 8 AM ET Monday, Oct. 12, the biggest favorites were the Los Angeles Rams against Arizona (86 cents to win, 12.5 points at DraftKings), the Kansas City Chiefs against the Chargers (79 cents, 8.5 points) and the San Francisco 49ers against Washington on Monday night (78 cents, 7.5 points). The Patriots (76 cents) and Colts (75 cents) were next, both 7-point favorites.

Is Lamar Jackson playing in Week 6?

Unknown as of Monday. Jackson missed Week 5 with an ankle injury and Tyler Huntley started at Atlanta. Our Week 6 board prices Ravens at Browns with Huntley until Baltimore says otherwise, and Kalshi had the Ravens at 70 cents on Monday morning. In Huntley's start, Derrick Henry's share of the carries was 69%, close to his 70% with Jackson in Weeks 1–4. What changed was the passing volume: Huntley threw 32 times.

Who starts at quarterback for the Falcons in Week 6?

Michael Penix Jr. left Sunday night's overtime loss to Baltimore with a rib injury, and Tua Tagovailoa finished the game. Penix predicted he will return next week, per the AP. Our page for Bears at Falcons shows the game both ways, with Penix and with Tagovailoa, until the Falcons name a starter.

Where do the targets go if CeeDee Lamb or Deebo Samuel miss Week 6?

In Week 5, with Lamb limited by a quad injury (five targets), George Pickens drew 13 of Dallas's 42. In Week 5 at Seattle, the game Samuel left in the third quarter with a hamstring injury, Mike Evans drew 10 of San Francisco's 27 targets, a 37% share, and George Kittle drew six.

Which NFL Week 6 lines have moved the most?

At DraftKings via ESPN, Panthers at Eagles moved from Philadelphia minus 6.5 to minus 1.5, Chargers at Chiefs from Kansas City minus 2.5 to minus 8.5, Texans at Jaguars from Houston minus 1.5 to Jacksonville minus 3, and Steelers at Buccaneers from Tampa Bay minus 1.5 to Pittsburgh minus 3. The biggest total moves were Cardinals at Rams (46.5 to 52.5), Bills at Raiders (47.5 to 52.5) and Steelers at Buccaneers (45.5 to 40.5).

Are these prices still live?

No. Kalshi prices here were read at 8 AM ET Monday, Oct. 12, and DraftKings lines via ESPN the same morning, before any Week 6 injury report. They will move as reports post Wednesday through Friday. Every game page updates live.

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The 7 Oracles is the analyst collective behind PredictionMarketsPicks — calibrated, data-first coverage of Kalshi, Polymarket, DraftKings, and FanDuel markets.

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NFL Week 6 predictionsNFL Week 6 predictions 2026NFL Week 6 picksNFL Week 6 injuriesNFL Week 6 odds KalshiLamar Jackson Week 6Michael Penix Jr. injuryBaker Mayfield returnCeeDee Lamb injury Week 6Deebo Samuel hamstringRavens vs Browns predictionBears vs Falcons predictionCowboys vs Packers predictionSeahawks vs Broncos predictionChargers vs Chiefs predictionCommanders vs 49ers predictionDerrick Henry rushing yards Week 6

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